Design, synthesis, and biological evaluation of multiple F-18 S1PR1 radiotracers in rodent and nonhuman primate

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We synthesized and screened 28 new fluorine-containing S1PR1 compounds; 9 potent and selective compounds were F-18 radiolabeled with good radiochemical yields. In vivo PET imaging evaluation was performed for these radiotracers as CNS imaging agents.