What question did this study set out to answer?

To assess the effects of ibuprofen on blood pressure control in patients receiving treatment with antihypertensive medications.

November 1, 1987Annals of Internal Medicine

Ibuprofen Interferes with the Efficacy of Antihypertensive Drugs

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Why the study?

Does ibuprofen interfere with blood pressure control in patients with essential hypertension treated with at least two antihypertensive drugs?

Population

45 patients with essential hypertension controlled by treatment with at least two antihypertensive drugs.

Comparison

Ibuprofen 400 mg orally every 8 hours for 3… vs Acetaminophen 1 g orally every 8 hours or…

Design

RCT, Randomized, Blinded, placebo-controlled

Follow-up

3 weeks

Authors

KRKenneth L. RadackUniversity of Cincinnati

Discussion

Member takes

Implication

Ibuprofen warrants BP monitoring or avoidance in treated hypertensive patients; confirms NSAID interference with control on multiple antihypertensives.

Key Points

To assess the effects of ibuprofen on blood pressure control in patients receiving treatment with antihypertensive medications.
Randomized, blinded, placebo-controlled parallel trial of 45 patients with essential hypertension controlled by at least two antihypertensive drugs at a university hospital internal medicine clinic (41 completed).
Participants received oral ibuprofen (400 mg every 8 hours), acetaminophen (1 g every 8 hours), or placebo (2 capsules every 8 hours) for 3 weeks while continuing their baseline antihypertensive regimens.
Ibuprofen led to significant within-group increases from baseline in supine diastolic blood pressure (mean increase: 6.4 mm Hg; 95% CI, 1.05 to 11.75; p = 0.0239), supine mean arterial pressure (6.6 mm Hg; 95% CI, 1.25 to 11.95; p = 0.0205), and sitting mean arterial pressure (5.8 mm Hg; 95% CI, 1.57 to 10.04; p = 0.0123).
Compared with placebo after 3 weeks, ibuprofen significantly increased supine systolic pressure (7.1 mm Hg vs. -4.5 mm Hg; difference 95% CI, 2.5 to 20.6; p = 0.0133), supine diastolic pressure (6.4 mm Hg vs. 0.0 mm Hg; difference 95% CI, 0.87 to 12.4; p = 0.0250), and sitting systolic pressure (6.8 mm Hg vs. -3.7 mm Hg; difference 95% CI, 2.0 to 19.0; p = 0.0169).
Ibuprofen also caused statistically significant elevations in supine diastolic and mean arterial pressures, as well as sitting diastolic and mean arterial pressures, compared with acetaminophen.

Structured PICO

Does ibuprofen interfere with blood pressure control in patients with essential hypertension treated with at least two antihypertensive drugs?

Population

45 patients with essential hypertension controlled by treatment with at least two antihypertensive drugs.

Intervention

Ibuprofen 400 mg orally every 8 hours for 3 weeks, added to previous antihypertensive regimens.

Comparator

Acetaminophen 1 g orally every 8 hours or placebo 2 capsules orally every 8 hours for 3 weeks, added to previous antihypertensive regimens.

Outcome

Change in supine and sitting systolic, diastolic, and mean arterial blood pressures from baseline after 3 weeks of treatment.surrogate

Ibuprofen, but not acetaminophen, significantly increases blood pressure in patients with controlled essential hypertension on multiple antihypertensive medications.

Cite This Study

Kenneth L. Radack (1987) studied this question.

synapsesocial.com/papers/6a987a8f48a7dbe01cbc4a31 https://doi.org/10.7326/0003-4819-107-5-628

Topics

Hypertension management

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Implication

Ibuprofen warrants BP monitoring or avoidance in treated hypertensive patients; confirms NSAID interference with control on multiple antihypertensives.

Ibuprofen Interferes with the Efficacy of Antihypertensive Drugs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Ibuprofen Interferes with the Efficacy of Antihypertensive Drugs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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