Key result
During chick embryonic development, Angptl1-4 and 7 exhibit distinct spatial and temporal expression patterns in various developing organs, suggesting roles in angiogenesis during organogenesis.
Population
Chick embryos at developmental stages embryonic day 3 (E3) and day 4 (E4)
Design
Preclinical
Authors
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Hypothesis-generating for ANGPTL roles in developmental angiogenesis; requires functional validation before translational relevance.
Distinct expression patterns of ANGPTL family members during chick embryonic development suggest their involvement in angiogenesis during organogenesis.
Niki et al. (2009) studied Chick embryonic development. Expression patterns of Angptl1, 2, 3, 4, 5, and 7 orthologues was evaluated on Expression patterns using whole-mount in situ hybridization. During chick embryonic development, Angptl1-4 and 7 exhibit distinct spatial and temporal expression patterns in various developing organs, suggesting roles in angiogenesis during organogenesis.
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