Key result
Four TCF/LEF-binding sites within the human ANGPTL7 promoter were conserved in the chimpanzee ANGPTL7 promoter, whereas only an unrelated TCF/LEF-binding site occurred in mouse and rat promoters.
Population
Human, chimpanzee, mouse, and rat genomic sequences (ANGPTL7 orthologs)
Design
Preclinical
Authors
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Species differences in ANGPTL7 promoter conservation caution rodent-to-human extrapolation; leaves open primate-specific WNT targeting as a pharmacogenomics hypothesis.
Human ANGPTL7 is characterized as a potent target gene of the WNT/beta-catenin signaling pathway, with conserved TCF/LEF-binding sites in primates but not rodents, highlighting its potential as a pharmacogenomics target.
Katoh et al. (2006) studied this question. Four TCF/LEF-binding sites within the human ANGPTL7 promoter were conserved in the chimpanzee ANGPTL7 promoter, whereas only an unrelated TCF/LEF-binding site occurred in mouse and rat promoters.
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