Thermal resistance and urea resistance in poliovirus are independent genetic markers, suggesting a lack of covariance between the two inactivation pathways.
Hypothesis-generating for poliovirus attenuation; leaves open whether markers predict stability or virulence in clinical settings.
Hallum, J. V. (University of Pittsburgh, Pittsburgh, Pa.), and J. S. Youngner. Urea and thermal mutants of poliovirus. J. Bacteriol. 91:2305-2308. 1966.-Thermally selected mutants of poliovirus which differed in sensitivity to heating at 50 C were inactivated with urea. With 3 m urea, urea resistance paralleled thermal resistance. In contrast, when urea-resistant mutants were selected from thermosensitive, urea-sensitive, wild-type poliovirus, the 50 C sensitivity of the selected mutants did not change. These findings indicate a lack of covariance of the urea and the 50 C-inactivation markers of poliovirus.
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Hallum et al. (1966) studied this question.
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