Why the study?
Does clofibrate improve cardiac performance and reduce myocardial injury during ischemia and reperfusion in experimental pigs?
Population
Experimental pigs whose isolated in situ hearts were subjected to 60 min of regional ischemia, followed by…
Comparison
Clofibrate fed for 9 days vs Control pigs
Design
Preclinical
Follow-up
9 days of feeding followed by acute experiment
Authors
Loading...
Hypothesis-generating for ischemia-reperfusion injury; clinical use unsupported without human trials.
Does clofibrate improve cardiac performance and reduce myocardial injury during ischemia and reperfusion in experimental pigs?
Clofibrate feeding in a porcine model reduces myocardial injury and improves cardiac performance during ischemia and reperfusion, likely by decreasing free fatty acids and increasing catalase activity.
Prasad et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: