Key result
Copeptin was an independent predictor of death (P<0.0001) and heart failure re-hospitalization (P<0.05) in patients with advanced heart failure.
Why the study?
Does copeptin predict death and re-hospitalization in patients with advanced heart failure?
Population
268 patients with advanced heart failure after they had been discharged from the hospital
Design
Cohort
Follow-up
mean 15.8 months (up to 24 months)
Authors
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Cautions against routine copeptin use in advanced HF; supports prospective validation for risk stratification.
Cohort (n=268)
Does copeptin predict death and re-hospitalization in patients with advanced heart failure?
p-value: p=<0.0001
Copeptin is a strong, independent predictor of mortality and heart failure re-hospitalization in patients with advanced heart failure, potentially offering superior prognostic value to BNP for mortality.
Stoiser et al. (2006) conducted a cohort in advanced heart failure (n=268). Copeptin vs. BNP was evaluated on Death, re-hospitalization due to heart failure, and a combination of the two (p=<0.0001). Copeptin was an independent predictor of death (P<0.0001) and heart failure re-hospitalization (P<0.05) in patients with advanced heart failure.
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