Key result
The rs7308402 AG genotype of the nNOS gene was associated with a reduced risk of ischemic stroke in Han Chinese of North China (OR 0.572; 95% CI 0.335-0.978; P=0.041).
Why the study?
Is nNOS gene polymorphism associated with ischemic stroke in Han Chinese of North China?
Case-Control (n=890)
Is nNOS gene polymorphism associated with ischemic stroke in Han Chinese of North China?
Odds Ratio: 0.572 (95% CI 0.335–0.978)
p-value: p=0.041
The rs7308402 gene polymorphism of nNOS (AG genotype and A allele) is a protective factor against ischemic stroke in the Han Chinese population of North China.
Hypothesis-generating for nNOS rs7308402 in stroke risk among Han Chinese; requires validation before any clinical application.
Nitric oxide (NO) is an important messenger molecule and effector molecule. This study aimed to investigate the relation of neuronal nitric oxide synthase (nNOS) gene polymorphism with ischemic stroke in Han Chinese of North China. This was a case-control study. A total of 413 patients with ischemic stroke were recruited from Han Chinese of North China. There were 201 males and 212 females. In addition, 477 healthy subjects served as controls including 224 males and 253 females. Multiplex SNaPshot was employed to detect nNOS gene polymorphism (rs2293050, rs2139733, rs7308402, and rs1483757). Results showed that the rs1483757, rs2139733, and rs2293050 genotypes and allele frequencies were comparable between patients and controls. However, ischemic stroke patients had significantly reduced AG genotype and A allele frequency when compared with controls (P = 0.037, P = 0.041). After adjusting confounding factors (gender, age, smoking, history of drinking, hypertension, and diabetes), AG genotype and A allele were still related to ischemic stroke (OR = 0.572, 95% CI: 0.335-0.978, P = 0.041; OR = 0.611, 95% C: 0.378-0.985, and P = 0.041) and both were found to be protective factors. Our results showed that rs7308402 gene polymorphism of nNOS is related to ischemic stroke in Han Chinese of North China.
No takes yet. Share an insight, caveat, or question.
Dai et al. (2013) conducted a case-control in Ischemic stroke (n=890). nNOS gene polymorphism (rs7308402) vs. Healthy controls was evaluated on Ischemic stroke (OR 0.572, 95% CI 0.335-0.978, p=0.041). The rs7308402 AG genotype of the nNOS gene was associated with a reduced risk of ischemic stroke in Han Chinese of North China (OR 0.572; 95% CI 0.335-0.978; P=0.041).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: