Key result
Amiloride and losartan in combination completely prevented right ventricular hypertrophy and normalized LV responses to pressure and volume load after myocardial infarction in rats.
Why the study?
Does the combination of amiloride and losartan prevent cardiac remodeling and LV dysfunction after myocardial infarction in rats?
Population
Rats undergoing coronary artery ligation (myocardial infarction model)
Comparison
Amiloride, losartan, or amiloride and losartan… vs No treatment
Design
Preclinical, randomly allocated
Follow-up
4 weeks
Authors
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Supports complementary post-MI remodeling effects in rats; leaves open translation to human therapy.
RCT
randomly allocated
Does the combination of amiloride and losartan prevent cardiac remodeling and LV dysfunction after myocardial infarction in rats?
The combination of amiloride and losartan appears complementary in preventing cardiac remodeling and LV dysfunction after myocardial infarction in a rat model.
Ruzicka et al. (1999) conducted an RCT in myocardial infarction. Amiloride and losartan in combination vs. No treatment, amiloride alone, or losartan alone was evaluated on Left ventricular function and cardiac remodeling. Amiloride and losartan in combination completely prevented right ventricular hypertrophy and normalized LV responses to pressure and volume load after myocardial infarction in rats.
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