Key result
Type 2 diabetes patients had significantly lower insulin-mediated arterio-venous glucose extraction in the arm compared to controls (4.7% vs 6.9%; P=0.029).
Why the study?
Is insulin-mediated glucose clearance different between arm and leg muscles in patients with type 2 diabetes compared to controls?
Observational (n=12)
Is insulin-mediated glucose clearance different between arm and leg muscles in patients with type 2 diabetes compared to controls?
Absolute Event Rate: 4.7% vs 6.9%
p-value: p=0.029
Glucose clearance is higher in arm than leg muscles regardless of insulin resistance, suggesting better preserved insulin sensitivity in arm muscle in type 2 diabetes.
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Supports relatively preserved arm versus leg insulin sensitivity in type 2 diabetes; hypothesis-generating and should not yet change practice.
Olsen et al. (2005) conducted an observational in Type 2 diabetes (n=12). Type 2 diabetes vs. Controls was evaluated on Arterio-venous glucose extraction in the arm during insulin clamp (p=0.029). Type 2 diabetes patients had significantly lower insulin-mediated arterio-venous glucose extraction in the arm compared to controls (4.7% vs 6.9%; P=0.029).
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