Why the study?
Does type 2 diabetes reduce muscle capillary permeability surface area for glucose and insulin compared to obese controls during hyperinsulinemia?
Population
Type 2 diabetic male subjects and age- and weight-matched controls (obese subjects)
Comparison
Euglycemic-hyperinsulinemic clamp with… vs Age- and weight-matched controls (obese subjects)
Design
Case-control
Authors
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May worsen insulin resistance in type 2 diabetes; leaves open whether capillary permeability is causal or modifiable.
Does type 2 diabetes reduce muscle capillary permeability surface area for glucose and insulin compared to obese controls during hyperinsulinemia?
Type 2 diabetic subjects have a subnormal permeability-surface area product for glucose during hyperinsulinemia, suggesting that impaired transcapillary passage may further aggravate insulin resistance.
Guðbjörnsdóttir et al. (2005) studied this question.
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