Key result
Pulmonary arterial hypertension was associated with significantly higher myocardial T1-values compared to controls, peaking at the RV insertion points (MD 108 ms; 95% CI 89-128).
Why the study?
Elevated CMR T1-mapping and extracellular volume reflect myocardial abnormalities, but a pooled summary comparing these values in pulmonary arterial hypertension against controls was needed.
Are myocardial T1-mapping and ECV values measured on CMR significantly elevated in adults with pulmonary arterial hypertension compared to healthy controls?
Meta-Analysis (n=674)
Are myocardial T1-mapping and ECV values measured on CMR significantly elevated in adults with pulmonary arterial hypertension compared to healthy controls?
Mean Difference: 108 (95% CI 89–128)
Myocardial T1-mapping and ECV values are significantly elevated in patients with PAH compared to controls, particularly at the RV insertion points, and correlate with poor RV function.
No takes yet. Share an insight, caveat, or question.
May inform myocardial assessment in PAH; leaves open prognostic utility and therapeutic guidance pending prospective validation.
Alabed et al. (2021) conducted a meta-analysis in Pulmonary arterial hypertension (PAH) (n=674). Pulmonary arterial hypertension vs. Controls was evaluated on T1-values at the RV insertion points (RVIP) (MD 108 ms, 95% CI 89 to 128). Pulmonary arterial hypertension was associated with significantly higher myocardial T1-values compared to controls, peaking at the RV insertion points (MD 108 ms; 95% CI 89-128).
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