Key result
Cardiac syndrome X was associated with significantly higher erythrocyte aggregation index (72.758 vs 66.483, p=0.002) and plasma viscosity, and lower erythrocyte deformability compared to controls.
Case-Control (n=63)
Hemorheological impairments, including increased erythrocyte aggregation and decreased deformability, are associated with cardiac syndrome X.
Hemorheological changes were associated with CSX; leaves open causal role and therapeutic relevance pending prospective studies.
Background: Cardiac syndrome X (CSX) is often described as angina or angina-like chest pain with a normal coronary arteriogram, yet the underlying pathophysiological mechanisms have not been fully elucidated. The aim of the current study was to determine alterations in blood rheology (erythrocyte aggregation and deformability, plasma viscosity – PV) in patients with CSX.Methods: The study comprised 26 CSX patients (55.77 ± 12.33 years) and 37 age- and sex-matched (56.32 ± 11.98 years) healthy controls. Erythrocyte aggregation and deformability were measured by an ektacytometer and PV with a rotational viscometer.Results: Erythrocyte deformability measured at 1.69 and 3.00 Pa was lower in the CSX patients compared to the controls (p = .0001 and .017, respectively). Erythrocyte aggregation index (AI) (72.758 ± 7.65 vs. 66.483 ± 6.63, p = .002) and PV measured at a shear rate of 375 s−1 (1.932 ± 0.225 vs. 1.725 ± 0.331, p = .019) were significantly higher in patients with CSX. When AI, RDW and erythrocyte deformability measured at 1.69 Pa were evaluated together, it was observed that the increase in AI and RDW augments the risk of having CSX (OR: 1.2 and 2.65, respectively), while the rise in deformability decreases this risk (OR = 0.02).Conclusions: Hemorheological impairments are associated with CSX.
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Kılıç-Toprak et al. (2017) conducted a case-control in Cardiac syndrome X (n=63). Cardiac syndrome X vs. Healthy controls was evaluated on Erythrocyte aggregation index (AI) (p=0.002). Cardiac syndrome X was associated with significantly higher erythrocyte aggregation index (72.758 vs 66.483, p=0.002) and plasma viscosity, and lower erythrocyte deformability compared to controls.
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