Key result
Cardiac resynchronization therapy increased cardiac output by 25±5% (P<0.05) and improved other hemodynamic variables in heart failure patients with a narrow QRS and no dyssynchrony.
Why the study?
Does cardiac resynchronization therapy improve short-term hemodynamics in heart failure patients with LVEF <=35%, narrow QRS (<120 ms), and no dyssynchrony?
Population
30 heart failure patients with a left ventricular ejection fraction <=35% who were in sinus rhythm, with a…
Comparison
Biventricular and left ventricular pacing… vs Baseline (before delivery of pacing).
Design
Cohort
Follow-up
Short-term
Authors
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Observed hemodynamic gains should not change practice in narrow-QRS HF; leaves open need for randomized outcome trials.
Does cardiac resynchronization therapy improve short-term hemodynamics in heart failure patients with LVEF <=35%, narrow QRS (<120 ms), and no dyssynchrony?
Effect estimate: Cardiac output increased by 25±5%
p-value: p=<0.05
Cardiac resynchronization therapy improves short-term hemodynamics in heart failure patients with narrow QRS and no dyssynchrony by enhancing contractility and relieving external constraint.
Williams et al. (2009) studied Heart failure (n=30). Cardiac resynchronization therapy vs. Baseline (before pacing) was evaluated on Short-term hemodynamic variables (cardiac output, left ventricular stroke work, dP/dtmax) (Cardiac output increased by 25±5%, p=<0.05). Cardiac resynchronization therapy increased cardiac output by 25±5% (P<0.05) and improved other hemodynamic variables in heart failure patients with a narrow QRS and no dyssynchrony.