Key result
Insulin resistance reduced cardiac microvascular density by 30% and inhibited insulin-stimulated VEGF expression by 40% via the PI3K/Akt pathway in animal models.
Why the study?
Does insulin regulate VEGF expression and myocardial vascularization via the PI3K/Akt pathway in physiological conditions and after ischemia?
Population
Preclinical models including insulin-resistant Zucker fatty rats, lean controls, cultured cardiomyocytes…
Comparison
Insulin or insulin-like growth factor-1… vs Lean controls, untreated cardiomyocytes, and…
Design
Preclinical
Authors
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May impair myocardial angiogenesis in insulin resistance; leaves open whether PI3K/Akt activation improves vascularization in human ischemia models.
Does insulin regulate VEGF expression and myocardial vascularization via the PI3K/Akt pathway in physiological conditions and after ischemia?
Insulin regulates VEGF gene expression and myocardial vascularization specifically via insulin receptors and the PI3K/Akt pathway, which is impaired in insulin resistance.
He et al. (2006) studied Insulin resistance and ischemia. Insulin resistance and insulin receptor knockout vs. Lean controls / wild-type controls was evaluated on Cardiac microvascular density and VEGF expression. Insulin resistance reduced cardiac microvascular density by 30% and inhibited insulin-stimulated VEGF expression by 40% via the PI3K/Akt pathway in animal models.
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