Population
Right ventricular papillary muscles from reserpine-pretreated guinea-pigs (250-350g)
Comparison
Muscarinic receptor agonists vs Control conditions and presence of muscarinic…
Design
Preclinical
Authors
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Dual muscarinic inotropy in animal ventricle leaves open selective modulation for human contractility disorders; prospective studies required.
Muscarinic receptors in mammalian ventricular myocardium mediate both negative and positive inotropic effects that differ in concentration-dependence by a factor of 100, suggesting distinct underlying mechanisms.
Korth et al. (1987) studied this question.
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