Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1998Arteriosclerosis Thrombosis and Vascular Biology

Plasma Levels of Activated Protein C in Healthy Subjects and Patients With Previous Venous Thromboembolism

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are plasma levels of activated protein C (APC) elevated in patients with previous venous thromboembolism and hyperhomocysteinemia compared to healthy controls?

Population

128 patients with previous venous thromboembolism and 98 age- and sex-matched healthy controls. No known…

Design

Case-control

Authors

MCMarco CattaneoVascular MedicineFFFranca FranchiUniversity of InsubriaMZMaddalena L. ZighettiAOL (United States)

Discussion

Loading...

Member takes

Implication

APC elevation may mark in vivo hemostatic activation in hyperhomocysteinemic VTE; leaves open biomarker utility for risk stratification.

Structured PICO

Are plasma levels of activated protein C (APC) elevated in patients with previous venous thromboembolism and hyperhomocysteinemia compared to healthy controls?

P
Population
128 patients with previous venous thromboembolism (VTE) (48 with hyperhomocysteinemia, 80 with normal tHcy) and 98 age- and sex-matched healthy controls. No known congenital or acquired thrombophilic states.
C
Comparator
98 age- and sex-matched healthy controls
O
Outcome
Plasma levels of activated protein C (APC) and APC/PC ratiossurrogate

APC plasma levels are sensitive markers of in vivo hemostatic system activation, and homocysteine does not appear to interfere with protein C activation in vivo.

Cite This Study

Cattaneo et al. (1998) studied this question.

synapsesocial.com/papers/6a98ff0be8ca4d2af6362dd0https://doi.org/10.1161/01.atv.18.9.1371

Topics

Pulmonary embolism
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Laboratory Diagnosis of APC-Resistance: A Critical Evaluation of the Test and the Development of Diagnostic Criteria1994 · 192 citations
  2. 2A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis1996 · 3,130 citations
  3. 3Markers of Procoagulant Imbalance in Patients with Inherited Thrombophilic Syndromes1992 · 69 citations