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January 1, 2015Advances in Clinical and Experimental MedicineOpen Access

Determinants of Elevated Levels of Natural Anticoagulants in Healthy Subjects

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Population

130 healthy adults, aged 20-60 years. Excluded individuals with personal or family history of cardiovascular…

Design

Cross-sectional

Authors

BKBarbara KościelniakJagiellonian UniversityEWEwa WypasekJohn Paul II HospitalAUAnetta UndasVascular Medicine

Discussion

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Implication

Should not change thromboprophylaxis in healthy adults; leaves open whether elevated protein C compensates for metabolic and inflammatory prothrombotic stress.

Structured PICO

P
Population
130 healthy adults (67 females, 63 males), aged 20-60 years (median 41). Excluded individuals with personal or family history of cardiovascular diseases and venous thromboembolism.
O
Outcome
Factors determining elevated levels of natural plasma anticoagulants (protein C, free protein S, and antithrombin)surrogate

In healthy adults, elevated levels of natural anticoagulants like protein C and free protein S are associated with hypercholesterolemia, overweight, and increased CRP, which may reflect a defense mechanism against coagulation activation.

Cite This Study

Kościelniak et al. (2015) studied this question.

synapsesocial.com/papers/6a70811326a7f98052dcffeehttps://doi.org/10.17219/acem/44361
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations of protein C and protein S with serum lipid concentrations1998 · 22 citations
  2. 2Correlation of Plasma Protein C Levels with Cardiovascular Risk Factors in Middle-Aged Adults: The Atherosclerosis Risk in Communities (ARIC) Study1993 · 47 citations
  3. 3Venous thrombosis: who should be screened for thrombophilia in 2014?2013 · 18 citations
  4. 4C-Reactive Protein Promotes Monocyte Chemoattractant Protein-1—Mediated Chemotaxis Through Upregulating CC Chemokine Receptor 2 Expression in Human Monocytes2004 · 194 citations
  5. 5The VITA Project: Population-based Distributions of Protein C, Antithrombin III, Heparin-cofactor II and Plasminogen -Relationship with Physiological Variables and Establishment of Reference Ranges1996 · 50 citations