Key result
Aneurysm rupture significantly increased the risk of long-term mortality after open surgical repair compared to non-ruptured aneurysms (HR 1.96), with 10-year survival rates of 54.1% versus 83.4%.
Why the study?
Does open surgical repair for ruptured AAA compared to non-ruptured AAA affect long-term survival?
Cohort (n=455)
No
Does open surgical repair for ruptured AAA compared to non-ruptured AAA affect long-term survival?
Hazard Ratio: 1.96 (95% CI 1.12–3.44)
Absolute Event Rate: 54.1% vs 83.4%
p-value: p=0.01
After excluding in-hospital mortality, age and aneurysm rupture remain significant risk factors affecting long-term survival in patients undergoing open surgical repair for abdominal aortic aneurysm.
Ruptured AAA signals higher long-term mortality after open repair; leaves open whether targeted strategies can narrow the gap.
PURPOSE: The aim of this study was to confirm the factors that affect the mortality associated with the open surgical repair of ruptured abdominal aortic aneurysm (rAAA) and to analyze the long-term survival rates. METHODS: A retrospective review was performed on a prospectively collected database that included 455 consecutive patients who underwent open surgical repair for AAA between January 2001 and December 2012. We divided our analysis into in-hospital and postdischarge periods and analyzed the risk factors that affected the long-term survival of rAAA patients. RESULTS: Of the 455 patients who were initially screened, 103 were rAAA patients, and 352 were non-rAAA (nAAA) patients. In the rAAA group, 25 patients (24.2%) died in the hospital and 78 were discharged. Long-term survival was significantly better in the nAAA group (P = 0.001). The 2-, 5-, and 10-year survival rates of the rAAA patients were 87%, 73.4%, and 54.1%, respectively. Age (hazard ratio [HR], 1.05; 95% confidence interval [CI], 1.02-.08; P < 0.001) and aneurysm rupture (HR, 1.96; 95% CI, 1.12-.44; P = 0.01) significantly affected long-term survival. CONCLUSION: Preoperative circulatory failure is the most common cause of death for in-hospital mortality of rAAA patients. After excluding patients who have died during the perioperative period, age is the only factor that affects the survival of rAAA patients.
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Gwon et al. (2016) conducted a cohort in Abdominal aortic aneurysm (n=455). Ruptured abdominal aortic aneurysm vs. Non-ruptured abdominal aortic aneurysm was evaluated on Long-term survival (excluding in-hospital mortality) (HR 1.96, 95% CI 1.12-3.44, p=0.01). Aneurysm rupture significantly increased the risk of long-term mortality after open surgical repair compared to non-ruptured aneurysms (HR 1.96), with 10-year survival rates of 54.1% versus 83.4%.
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