Thiols and disulphides can aggravate peroxynitrite‐dependent inactivation of α1‐antiproteinase
Population
In vitro biochemical model evaluating alpha1-antiproteinase (alpha1AP)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Suggests caution selecting thiols as peroxynitrite scavengers; leaves open in vivo relevance and clinical translation.
Structured PICO
P
Population
In vitro biochemical model evaluating alpha1-antiproteinase (alpha1AP)
I
Intervention
Various thiols and disulphides (captopril, penicillamine, cysteine, cystine, penicillamine disulphide, GSH, GSSG, homocysteine, ergothioneine, N-acetylcysteine, lipoate, dihydrolipoate)
O
Outcome
Inactivation of alpha1-antiproteinase (alpha1AP) by peroxynitrite (ONOO-)surrogate
Certain thiols and disulphides can aggravate peroxynitrite-dependent inactivation of alpha1-antiproteinase, suggesting caution when using thiols as peroxynitrite scavengers.
Cite This Study
Whiteman et al. (1997) studied this question.