Why the study?
Does vascular responsiveness to norepinephrine or angiotensin II differ between hypotensive and normotensive patients on long-term hemodialysis?
Does vascular responsiveness to norepinephrine or angiotensin II differ between hypotensive and normotensive patients on long-term hemodialysis?
Diminished vascular responsiveness to pressors may contribute to the development of hypotension in patients on long-term hemodialysis.
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Diminished pressor responsiveness may underlie dialysis hypotension; hypothesis-generating and requires prospective confirmation before clinical adoption.
The vascular responsiveness and the body fluid distribution were studied in 5 hypotensive and 11 normotensive patients on long-term hemodialysis. A diminished vascular responsiveness to intravenously infused norepinephrine or angiotensin II was found in uremic patients, especially in the hypotensive group. A slightly larger, but non-significant circulating blood volume (CBV) and a less extracellular fluid volume (ECF) was found in the hypotensive group as compared with those of the normotensive group. These results suggest that with autonomic nervous dysfunction, such a diminution of vascular responsiveness may be an another factor responsible for the development of hypotension.
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Tajiri et al. (1980) studied this question.
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