Key result
Haemodialysis in patients with chronic renal failure caused a fall in blood pressure during head-up tilt, driven by decreased cardiac output and an unresponsive renin-angiotensin system.
Why the study?
What are the mechanisms of hypotension during haemodialysis in patients with chronic renal failure?
Population
11 patients with chronic renal failure and 17 normal subjects
Comparison
Haemodialysis and furosemide diuresis vs Pre-intervention baseline and normal subject…
Design
Other
Authors
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Haemodialysis hypotension may reflect impaired cardiac output and renin-angiotensin responsiveness; leaves open dominant mechanisms versus autonomic factors.
Observational (n=28)
What are the mechanisms of hypotension during haemodialysis in patients with chronic renal failure?
Haemodialysis-induced hypotension may be driven by impaired myocardial function in response to fluid depletion or unresponsiveness of the renin-angiotensin system, rather than impaired autonomic reflexes.
Naik et al. (2008) conducted an observational in Chronic Renal Failure (n=28). Haemodialysis vs. Pre-haemodialysis state and normal subjects undergoing furosemide diuresis was evaluated on Cardiovascular reflexes, body fluid volumes, and osmolality responses to autonomic tests. Haemodialysis in patients with chronic renal failure caused a fall in blood pressure during head-up tilt, driven by decreased cardiac output and an unresponsive renin-angiotensin system.
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