Why the study?
Does centrally administered urotensin-II affect motor and cardioventilatory activity in trout?
Does centrally administered urotensin-II affect motor and cardioventilatory activity in trout?
Centrally administered urotensin-II induces motor activity and, at higher doses, cardioventilatory activation in trout, providing the first evidence of its central motor effects in a nonmammalian vertebrate.
Extends central urotensin-II motor effects to nonmammalian vertebrates; leaves open mammalian translation.
Although in most vertebrate species urotensin-II (UII) is synthesized in neurons of the central nervous system, little is known regarding the physiological actions of UII in the brain. We have investigated the effects of intracerebroventricular (ICV) administration of synthetic trout UII (1, 5, and 50 pmol) on total motor activity (ACT), ventilatory frequency (VF), ventilatory amplitude (VA), and heart rate (HR) in the unanesthetized trout. ICV injection of UII increased ACT in a dose-dependent manner, and the maximal effect was observed at a dose of 5 pmol. At doses of 1 and 5 pmol, UII did not affect VF, VA, or HR. At the highest dose tested (50 pmol), UII not only increased ACT, but also significantly activated VF, VA, and HR. In contrast, ICV injection of synthetic trout angiotensin-II (5 pmol) did not produce any effect on ACT, VF, or VA, but sharply increased HR. These data provide the first evidence that UII can act centrally to induce motor activity in a nonmammalian vertebrate species.
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Lancien et al. (2005) studied this question.
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