Population
In vitro biochemical study using human alpha-thrombin and alpha-thrombin-staphylocoagulase complex
Comparison
Alpha-thrombin-staphylocoagulase complex vs Free human alpha-thrombin
Design
Preclinical
Authors
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Alters thrombin kinetics in staphylocoagulase complex; hypothesis-generating for bacterial effects on coagulation, needs human validation.
The microenvironment of the active site of alpha-thrombin is significantly altered by complex formation with staphylocoagulase, reducing its catalytic ability and altering its sensitivity to inhibitors.
Kawabata et al. (1985) studied this question.
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