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The morphologies of the small proteins Zn2Cd5-metallothionein, cytochrome c3 and β-lactamase I immobilized inside carbon nanotubes have been studied by high-resolution transmission electron microscopy (HRTEM); single protein molecules and their associated forms were clearly observed inside the central cavity and a significant amount remained catalytically active indicating that no drastic conformational change had taken place.
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Tsang et al. (1995) studied this question.
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