Key result
Patients with acute coronary syndrome had significantly higher serum H2S levels (42.15 vs 21.04 micromol/L) and oxidative stress, alongside lower antioxidant defence compared to healthy controls.
Why the study?
Recent literature suggests a potential role for H2S and oxidative stress in regulating cardiovascular pathophysiology, but their levels and correlation in ACS warranted evaluation.
Are serum H2S levels associated with oxidative stress and antioxidant defence in patients with acute coronary syndrome?
Case-Control (n=104)
No
Are serum H2S levels associated with oxidative stress and antioxidant defence in patients with acute coronary syndrome?
Serum H2S levels are elevated in acute coronary syndrome and correlate positively with increased oxidative stress and reduced antioxidant defence.
Altered H2S and oxidative markers in ACS should not yet change practice; leaves open their prognostic or therapeutic relevance.
Introduction: A number of recent literatures suggest a potential role of H 2 S and oxidative stress in regulating cardiovascular pathophysiology. Aims and Objective: This study aimed to evaluate the serum levels of hydrogen sulfide (H 2 S), total oxidative stress (TOS) and total antioxidant defence (TAD) in the patients with acute coronary syndrome (ACS) and explore their correlation. Materials and Methods: Fifty two ACS patients and an equal number of healthy controls were included and serum H 2 S, TOS and TAD levels were measured. Results: The results showed significantly higher serum H2S and TOS levels and significantly lower TAD levels in ACS patients compared to controls. Positive correlation was observed between H2S and TOS, while negative correlation was found between H2S and TAD in the serum of ACS patients. These findings suggest that increased H2S levels are associated with oxidative stress and decreased antioxidant defence in ACS. Conclusion: The present study has revealed the increase in serum H 2 S levels in the patients with acute coronary syndrome as the total plasma oxidative stress increases with the subsequent reduction of total antioxidant defence.
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Prasenjit Pal Lakshmisona Mallik (2023) conducted a case-control in Acute Coronary Syndrome (n=104). Acute Coronary Syndrome vs. Healthy controls was evaluated on Serum H2S level (micromol/L) (p=<0.001). Patients with acute coronary syndrome had significantly higher serum H2S levels (42.15 vs 21.04 micromol/L) and oxidative stress, alongside lower antioxidant defence compared to healthy controls.
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