Key result
An 8-month-old boy with acute necrotizing encephalopathy associated with Adenovirus in the CSF showed clinical improvement after treatment with Cidofovir, corticosteroids, and IVIG.
Why the study?
Acute necrotizing encephalopathy of childhood is a rare entity that usually affects immunocompetent infants and children, mainly in East Asia, typically after a viral infection.
Case Report (n=1)
No
This case report highlights a rare instance of Adenovirus-induced acute necrotizing encephalopathy in an infant outside the typical East Asian demographic.
Answers are grounded in this paper and cite their sources.
Documents adenovirus-associated acute necrotizing encephalopathy in a Lebanese infant; hypothesis-generating for geographic distribution and management.
Acute necrotizing encephalopathy of childhood has been described as a rare entity that usually affects immunocompetent infants and children, mainly in East Asia, and typically after a viral infection. We describe the case of an 8-month-old, previously healthy Lebanese boy, who presented with fever and seizures and was found to have acute necrotizing encephalopathy with Adenovirus detected in the CSF. The clinical presentation and laboratory and radiological findings are described, and the outcomes are discussed.
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Chikhani et al. (2023) conducted a case report in Acute necrotizing encephalopathy of childhood (ANEC) (n=1). Medical management (Cidofovir, methylprednisolone, IVIG) was evaluated on Clinical outcome. An 8-month-old boy with acute necrotizing encephalopathy associated with Adenovirus in the CSF showed clinical improvement after treatment with Cidofovir, corticosteroids, and IVIG.
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