Key result
The combination of obstructive sleep apnea and hypertension had additive effects on markers of carotid atherosclerosis, significantly increasing intima-media thickness and carotid diameter (P<0.01).
Why the study?
Do obstructive sleep apnea and hypertension have additive effects on early markers of carotid atherosclerosis in middle-aged individuals?
Population
94 middle-aged participants free of smoking and diabetes mellitus, divided into 4 groups: controls, OSA…
Comparison
Obstructive sleep apnea and/or hypertension vs Controls (no OSA, no HTN)
Design
Cross-sectional
Authors
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Hypothesis-generating for additive vascular risk in comorbid OSA and hypertension; prospective studies needed before clinical adoption.
Cross-Sectional (n=94)
Do obstructive sleep apnea and hypertension have additive effects on early markers of carotid atherosclerosis in middle-aged individuals?
p-value: p=<0.01
The combination of obstructive sleep apnea and hypertension has additive adverse effects on early markers of carotid atherosclerosis, potentially explaining the increased cardiovascular risk in these patients.
Drager et al. (2008) conducted a cross-sectional in Obstructive sleep apnea and hypertension (n=94). Obstructive sleep apnea and hypertension vs. Controls, OSA alone, and HTN alone was evaluated on Carotid intima-media thickness, diameter, and distensibility (p=<0.01). The combination of obstructive sleep apnea and hypertension had additive effects on markers of carotid atherosclerosis, significantly increasing intima-media thickness and carotid diameter (P<0.01).
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