Why the study?
Does chronic chemical sympathectomy alter coronary blood flow and responsiveness to PGI2 in dog heart-lung preparations?
Does chronic chemical sympathectomy alter coronary blood flow and responsiveness to PGI2 in dog heart-lung preparations?
Chronic chemical sympathectomy augments the coronary blood flow increase in dog heart-lung preparations by potentiating the vasodilator response to PGI2 rather than increasing its production.
Supports mechanistic studies of sympathectomy on PGI2 responsiveness in isolated models; leaves open translation to clinical coronary regulation.
Chronic chemical denervation of the sympathetic nervous system with 6-OH dopamine resulted in an augmentation of the coronary blood flow (CBF) increase inherent in the canine heart-lung preparation, but not in an augmented accumulation of 6-keto PGF1 alpha in the circulating blood. In denervated HLP, 6-keto PGF1 alpha was lower and the vasodilator response to PGI2 larger at the start of the experiments. It was concluded that exaggerated increase in CBF was due to a potentiation of the vasodilator response to PGI2.
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Katano et al. (1985) studied this question.
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