The impact of preoperative neurological events in patients suffering from native infective valve endocarditis
Key result
A preoperative neurological event was an independent risk factor for in-hospital mortality in patients undergoing surgery for native valve endocarditis (OR 2.66; 95% CI 1.02-6.78; P=0.046).
Why the study?
Does a preoperative neurological event increase mortality in patients undergoing valve surgery for native infective valve endocarditis?
Population
495 patients who underwent valve surgery for the treatment of native infective valve endocarditis between…
Comparison
Valve surgery after a preoperative neurological… vs Valve surgery without a preoperative…
Design
Cohort
Follow-up
mean 4.0 ± 3.1 years
Authors
Discussion
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Implication
Preoperative neurological events may elevate in-hospital mortality risk in endocarditis valve surgery; leaves open long-term survival impact and management implications.
Study Design
Type
Cohort (n=495)
Structured PICO
Does a preoperative neurological event increase mortality in patients undergoing valve surgery for native infective valve endocarditis?
P
Population
495 patients undergoing valve surgery for native infective valve endocarditis, including 70 with a preoperative neurological event, followed for a mean of 4.0 years.
E
Exposure
Valve surgery after a preoperative neurological event (mean time interval between neurological event and surgery 8.7 ± 10.3 days)
C
Comparator
Valve surgery without a preoperative neurological event
O
Outcome
In-hospital mortality and mortality during further follow-uphard clinical
Main Result
Odds Ratio: 2.66 (95% CI 1.02–6.78)
p-value: p=0.046
In patients with native valve endocarditis, a preoperative neurological event increases in-hospital mortality risk but does not significantly impact long-term survival after valve surgery.
Cite This Study
Wilbring et al. (2014) conducted a cohort in Native infective valve endocarditis (NVE) (n=495). Preoperative acute neurological event vs. No preoperative acute neurological event was evaluated on In-hospital mortality (OR 2.66, 95% CI 1.02-6.78, p=0.046). A preoperative neurological event was an independent risk factor for in-hospital mortality in patients undergoing surgery for native valve endocarditis (OR 2.66; 95% CI 1.02-6.78; P=0.046).