Why the study?
Does early surgery reduce in-hospital mortality in patients with native valve endocarditis compared with medical therapy?
Population
1552 patients with definite native valve endocarditis (NVE) from a prospective, multinational cohort
Comparison
Early surgery vs Medical therapy
Design
Cohort
Follow-up
in-hospital
Authors
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May support early surgery in high-risk native valve endocarditis; hypothesis-generating and requires randomized confirmation.
Does early surgery reduce in-hospital mortality in patients with native valve endocarditis compared with medical therapy?
Early surgery for native valve endocarditis is associated with a significant reduction in in-hospital mortality compared to medical therapy alone, particularly in patients with high-risk features.
Lalani et al. (2010) studied this question.
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