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Two new alkaloids of conanine series, holamide (N-(N'-methylacetamido)-3-0x0-1 ,Cconadiene) (I), pubescinine (1 1~-acetoxy-N-demethyl-3-oxo-1,4,17(20)-conatriene) (2) and a known alkaloid norconessine (3-N-methylamino-5-conanene) (3), have been isolated from the bark of Holarrhena pubescens Buch.Ham (Holarrhena antidysenterica Linn.) (Apocynacea).Their structures have been established through spectroscopic studies.Both 1 and 2 showed hypotensive activity in rats at a dose of 3 mglkg.
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Siddiqui et al. (1995) studied this question.
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