Key result
PCI within 3 to 12 hours following thrombolytic therapy provided similar benefits on right ventricular systolic function compared to primary PCI in patients with RV-STEMI at one month.
Why the study?
Does thrombolytic therapy followed by PCI within 3 to 12 hours improve right ventricular systolic function similarly to primary PCI in patients with RV-STEMI?
Cohort (n=210)
Does thrombolytic therapy followed by PCI within 3 to 12 hours improve right ventricular systolic function similarly to primary PCI in patients with RV-STEMI?
PCI within 3 to 12 hours following thrombolytic therapy provides similar benefits on right ventricular systolic function recovery compared to primary PCI in patients with RV-STEMI.
RV systolic function changes in RV-STEMI may differ by PPCI versus thrombolysis; leaves open optimal strategy pending randomized trials.
OBJECTIVE: The level of right ventricular (RV) systolic function has prognostic importance in right ventricular ST-segment elevation myocardial infarction (RV-STEMI). This study aimed to evaluate the changes in RV systolic function in patients with RV-STEMI according to the revascularisation method used for their management. METHODS: The first group consisted of 132 patients who received primary percutaneous coronary intervention (PPCI). The 78 patients who had received thrombolytic therapy (TT) in external centres before referral to our centre for PCI within three to 12 hours of RV-STEMI were included in the second group. All patients were evaluated by conventional and two-dimensional speckle-tracking echocardiography. RESULTS: There were 172 male patients and their mean age was 63.7 ± 11.8 years. There were no significant differences between the two groups with regard to right ventricular systolic parameters at admission and at the one-month follow-up visit. The echocardiographic changes between admission and the one-month follow up were investigated for the patients included in the study groups. Mean values of each parameter observed at the one-month follow up were significantly increased compared to those at admission within each group. CONCLUSION: Our study demonstrated that PCI within three to 12 hours following TT provided similar benefits on right ventricular systolic function compared to PPCI in patients with RV-STEMI.
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Gül et al. (2016) conducted a cohort in Right ventricular ST-segment elevation myocardial infarction (RV-STEMI) (n=210). Thrombolytic therapy followed by PCI within 3 to 12 hours vs. Primary percutaneous coronary intervention (PPCI) was evaluated on Right ventricular systolic function at one month. PCI within 3 to 12 hours following thrombolytic therapy provided similar benefits on right ventricular systolic function compared to primary PCI in patients with RV-STEMI at one month.
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