July 22, 2022Acta Pharmaceutica Sinica BOpen Access

Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

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Why the study?

Does single-dose S663V-RBD vaccine improve SARS-CoV-2 specific immune responses in SPF 6-8-week-old female BALB/c mice?

Population

Mice

Comparison

Single-dose S663V-RBD vs licensed BBIBP-CorV

Follow-up

More than 4 months

Authors

FWFuhua WuSichuan University SLShuang LuoYunnan University YZYongshun ZhangQilu University of Technology

Discussion

Member takes

Implication

Does not support clinical adoption of S663V-RBD; leaves open its value as a durable, variant-resistant COVID-19 vaccine platform.

Structured PICO

Does single-dose S663V-RBD vaccine improve SARS-CoV-2 specific immune responses in SPF 6-8-week-old female BALB/c mice?

Population

Specific pathogen-free (SPF) 6-8-week-old female BALB/c mice and C57BL/6 mice

Intervention

Single-dose intramuscular injection of S663V-RBD (an adeno-associated viral serotype 6-based vaccine expressing trimeric receptor binding domain of spike protein fused with RS09 adjuvant)

Comparator

Licensed BBIBP-CorV (Sinopharm, China) given as two doses intraperitoneally, wild-type AAV6 (WT-RBD), and GFP controls

Outcome

RBD-specific IgG titer and pseudovirus neutralizing antibodies against wild type, C.37 (Lambda), and B.1.617.2 (Delta) SARS-CoV-2surrogate

A single-dose engineered AAV6-based SARS-CoV-2 vaccine (S663V-RBD) induces rapid, robust, and long-lasting neutralizing antibodies in mice, outperforming a licensed inactivated vaccine.

Cite This Study

Wu et al. (2022) studied this question.

synapsesocial.com/papers/6a9932e4ea739e5cccf5b2c5 https://doi.org/10.1016/j.apsb.2022.07.004

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Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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