Why the study?
Renal diseases caused by primary hypertension are often asymptomatic without sensitive markers for early diagnosis and prediction, easily progressing to severe and irreversible damage.
Does a set of urinary peptides predict new-onset proteinuria in patients with primary hypertension?
Population
319 participants, including healthy individuals and HTN patients with or without albuminuria
Comparison
High-risk vs low-risk groups based on urinary peptides cut-off value
Design
Prospective cohort study
Follow-up
Mean of 3.8 years
Authors
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May support early noninvasive detection of hypertensive renal damage; hypothesis-generating and requires prospective validation before clinical use.
Does a set of urinary peptides predict new-onset proteinuria in patients with primary hypertension?
A specific set of urinary peptides can accurately predict the development of new-onset proteinuria in patients with primary hypertension, allowing for earlier detection of hypertensive renal injury.
Lin et al. (2023) studied this question.
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