What does this research mean for the field?

Axial elongation in myopia is associated with region-specific peripapillary retinal nerve fiber layer changes and reduced macular vessel density, particularly in the deep capillary plexus. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the associations between axial length and retinal structural and microvascular parameters measured using optical coherence tomography and optical coherence tomography angiography.

September 3, 2026Translational Vision Science & TechnologyOpen Access

Axial Length-Associated Structural and Microvascular Retinal Changes in Myopia: A Combined OCT and OCTA Analysis

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Authors

KBKristina BelchevaAlexandrovska Hospital NDNikolai DakovAlexandrovska Hospital AOAlexander OscarAlexandrovska Hospital

Discussion

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Implication

Cross-sectional study reveals axial elongation correlates with peripapillary retinal nerve thinning and reduced deep macular vessel density, indicating distinct vascular profiles in myopic eyes.

Key Points

To evaluate the associations between axial length and retinal structural and microvascular parameters measured using optical coherence tomography and optical coherence tomography angiography.
Cross-sectional observational study evaluating 160 eyes from 160 participants stratified across four axial length categories (<24.00, 24.00–24.99, 25.00–25.99, and ≥26.00 mm).
Evaluated peripapillary retinal nerve fiber layer thickness and vessel density in the superficial, deep, and radial peripapillary plexuses using Kruskal-Wallis tests, correlations, and regression analyses.
Each 1-mm axial length increase was associated with superior (-2.24 µm) and inferior (-3.29 µm) peripapillary retinal nerve fiber layer thinning (P < 0.05), whereas nasal thickness showed a positive association.
Macular vessel density declined with increasing axial length, showing reductions of 0.29% in the superficial capillary plexus and 0.52% in the deep capillary plexus per 1-mm elongation.

Cite This Study

Belcheva et al. (2026) studied this question.

synapsesocial.com/papers/6a9935f3636c6408cfa7eafc https://doi.org/10.1167/tvst.15.9.1

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September 3, 2026Translational Vision Science & TechnologyOpen Access

Axial Length-Associated Structural and Microvascular Retinal Changes in Myopia: A Combined OCT and OCTA Analysis

View Full Paper

Ask AI

Bookmark

Authors

KBKristina BelchevaAlexandrovska Hospital NDNikolai DakovAlexandrovska Hospital AOAlexander OscarAlexandrovska Hospital

Discussion

Member takes

Implication

Cross-sectional study reveals axial elongation correlates with peripapillary retinal nerve thinning and reduced deep macular vessel density, indicating distinct vascular profiles in myopic eyes.

Key Points

To evaluate the associations between axial length and retinal structural and microvascular parameters measured using optical coherence tomography and optical coherence tomography angiography.
Cross-sectional observational study evaluating 160 eyes from 160 participants stratified across four axial length categories (<24.00, 24.00–24.99, 25.00–25.99, and ≥26.00 mm).
Evaluated peripapillary retinal nerve fiber layer thickness and vessel density in the superficial, deep, and radial peripapillary plexuses using Kruskal-Wallis tests, correlations, and regression analyses.
Each 1-mm axial length increase was associated with superior (-2.24 µm) and inferior (-3.29 µm) peripapillary retinal nerve fiber layer thinning (P < 0.05), whereas nasal thickness showed a positive association.
Macular vessel density declined with increasing axial length, showing reductions of 0.29% in the superficial capillary plexus and 0.52% in the deep capillary plexus per 1-mm elongation.

Cite This Study

Belcheva et al. (2026) studied this question.

synapsesocial.com/papers/6a9935f3636c6408cfa7eafc https://doi.org/10.1167/tvst.15.9.1

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