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August 28, 2026Photodiagnosis and Photodynamic TherapyOpen Access

Regional macular structure and microvasculature in children with low-to-moderate myopia: a cross-sectional OCT and OCTA study

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Authors

GTGetu TaoYLyu liuYZYifan Zhao

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Overview

Cross-sectional study reveals layer-specific macular microvascular alterations and retinal thinning in children with myopia, indicating early vascular remodeling as axial length increases.

Key Points

  • To characterize regional macular retinal thickness and layer-specific microvascular parameters in children with low-to-moderate myopia and evaluate their relationships with axial length.
  • Retrospective cross-sectional study evaluating 140 right eyes of children aged 8–14 years categorized into emmetropia (n = 30), low myopia (n = 70), and moderate myopia (n = 40) by cycloplegic spherical equivalent refraction.
  • Macular structural optical coherence tomography (OCT) and layer-specific OCT angiography (OCTA) were acquired using a Heidelberg Spectralis system, with multivariable regression applied to assess associations with axial length.
  • Superficial vascular complex (SVC) foveal avascular zone (FAZ) area and perimeter were significantly larger in moderate-myopic compared to low-myopic eyes (area: 0.57 ± 0.08 vs 0.51 ± 0.10 mm², P = 0.001; perimeter: 3.14 ± 0.22 vs 2.96 ± 0.41 mm, P = 0.012).
  • In the deep capillary plexus, moderate-myopic eyes exhibited lower vessel length density than emmetropic eyes, reduced fractal dimension relative to both groups, and larger FAZ area and perimeter than low-myopic eyes.
  • Longer axial length independently correlated with larger SVC FAZ area and perimeter, as well as thinning of the superior, nasal, and temporal perifoveal retina.

Cite This Study

Tao et al. (2026) studied this question.

synapsesocial.com/papers/6a9fddae3dfbbd0b17e61e9fhttps://doi.org/10.1016/j.pdpdt.2026.105633
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Choroidal structural and perfusion characteristics across refractive groups in children2026
  2. 2Retinal and choroidal structure and vascularity in Chinese emmetropic and myopic children2024 · 6 citations
  3. 3Differences in Retinal Thickness and Vessel Density of the Macula and Optic Disc Across Myopic Children and Adolescents2026
  4. 4Wide-field swept-source optical coherence tomography angiography (SS-OCTA) in the assessment of retinal vessel density and thickness in 4-to 16-year-old myopic children2024 · 2 citations
  5. 5Axial Length-Associated Structural and Microvascular Retinal Changes in Myopia: A Combined OCT and OCTA Analysis2026