What does this research mean for the field?

Activated platelets express the GPI-anchored receptor fibrocystin L (PKHD1L1) from granules, which is absent or deficient in paroxysmal nocturnal hemoglobinuria, and CD109 is also identified as a previously unreported granule protein. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Identify and characterize a novel ~500 kDa GPI-anchored receptor expressed on activated platelets and evaluate its expression in paroxysmal nocturnal hemoglobinuria.

September 3, 2026International Journal of Molecular SciencesOpen Access

Activated Platelets Express GPI-Anchored Fibrocystin-L (PKHD1L1), from Granules, Absent or Deficient in Paroxysmal Nocturnal Hemoglobinuria

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Authors

JPJános PolgárUniversity of Vermont JCJeannine M. ClemetsonUniversity of Bern EMEdith MagnenatOno Pharmaceutical (United States)

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Implication

Experimental study reveals activated platelets express granule-stored fibrocystin-L missing in paroxysmal nocturnal hemoglobinuria, indicating a novel marker and functional role in immunity.

Key Points

Identify and characterize a novel ~500 kDa GPI-anchored receptor expressed on activated platelets and evaluate its expression in paroxysmal nocturnal hemoglobinuria.
Isolated the ~500 kDa GPI-anchored surface receptor from activated human platelets and performed protein identification.
Conducted fluorescence microscopy studies on platelets using CD109 as a comparative control to assess subcellular localization.
Identified the ~500 kDa GPI-anchored protein as fibrocystin L (PKHD1L1), which is absent or deficient in platelets from patients with paroxysmal nocturnal hemoglobinuria.
Demonstrated that both fibrocystin L and the control receptor CD109 originate from platelet intracellular granules prior to surface expression upon activation.

Cite This Study

Polgár et al. (2026) studied this question.

synapsesocial.com/papers/6a993600636c6408cfa7ebdc https://doi.org/10.3390/ijms27177796

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Implication

Experimental study reveals activated platelets express granule-stored fibrocystin-L missing in paroxysmal nocturnal hemoglobinuria, indicating a novel marker and functional role in immunity.

Activated Platelets Express GPI-Anchored Fibrocystin-L (PKHD1L1), from Granules, Absent or Deficient in Paroxysmal Nocturnal Hemoglobinuria

Discussion

Member takes

Implication

Key Points

Cite This Study

Activated Platelets Express GPI-Anchored Fibrocystin-L (PKHD1L1), from Granules, Absent or Deficient in Paroxysmal Nocturnal Hemoglobinuria

Discussion

Member takes

Implication

Key Points

Cite This Study

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