What does this research mean for the field?

A short-term cognitive behavioural therapy (CBT) intervention significantly reduces depression, anxiety, and negative affect in individuals affected by or at risk for Huntington's disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To examine the efficacy of a short-term cognitive behavioral therapy intervention in reducing psychological distress and improving emotional well-being among individuals affected by Huntington's disease.

September 3, 2026Journal of Community GeneticsOpen Access

Psychological interventions for individuals affected by Huntington’s disease: effects on depression, anxiety, and emotional well-being

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Authors

ACAndrada CiucăBabeș-Bolyai University ȘTȘtefan TrifBabeș-Bolyai University SSSimona SamoilăBabeș-Bolyai University

Discussion

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Implication

Interventional study demonstrates reduced depression, anxiety, and negative affect in individuals affected by Huntington's disease, highlighting the utility of short-term cognitive behavioral therapy.

Key Points

To examine the efficacy of a short-term cognitive behavioral therapy intervention in reducing psychological distress and improving emotional well-being among individuals affected by Huntington's disease.
Recruited 21 participants affected by Huntington's disease (N=21; 38% premanifest HD, 29% at-risk, 33% HD-negative test; 57% women).
Administered an intervention consisting of eight online individual cognitive behavioral therapy sessions followed by two online group sessions.
Assessed anxiety, depression, positive and negative affect, and quality of life at pre-intervention, post-individual sessions, and post-group sessions.
Depression and anxiety scores showed statistically significant reductions with medium to large effect sizes.
Negative affect decreased significantly with a large effect size, while positive affect showed a non-significant trend toward improvement.
Quality-of-life measures, including physical and mental health components, demonstrated no statistically significant changes.

Cite This Study

Ciucă et al. (2026) studied this question.

synapsesocial.com/papers/6a993626636c6408cfa7f034 https://doi.org/10.1007/s12687-026-00923-6

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Psychological interventions for individuals affected by Huntington’s disease: effects on depression, anxiety, and emotional well-being

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Implication

Key Points

Cite This Study

Psychological interventions for individuals affected by Huntington’s disease: effects on depression, anxiety, and emotional well-being

Discussion

Member takes

Implication

Key Points

Cite This Study

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