Key result
Despite 25 years of standardization efforts, significant intra- and interlaboratory variation remains in anticardiolipin, lupus anticoagulant, and anti-beta2 glycoprotein I testing for APS.
Population
Patients with or suspected of having antiphospholipid syndrome (APS)
Design
Review
Authors
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Interpret APS serologic results with caution in clinical decisions; leaves open whether standardization can be achieved.
This review highlights the ongoing challenges with intra- and interlaboratory variation in antiphospholipid syndrome diagnostic testing despite decades of standardization attempts.
Pierangeli et al. (2008) conducted a review in Antiphospholipid syndrome (APS). Anticardiolipin (aCL) antibody testing was evaluated. Despite 25 years of standardization efforts, significant intra- and interlaboratory variation remains in anticardiolipin, lupus anticoagulant, and anti-beta2 glycoprotein I testing for APS.
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