Why the study?
Does a once-daily regimen of nitrendipine reduce blood pressure throughout the day in outpatients?
Does a once-daily regimen of nitrendipine reduce blood pressure throughout the day in outpatients?
Once-daily nitrendipine provides effective daytime blood pressure control but may not significantly affect early morning or wake-up blood pressure.
Answers are grounded in this paper and cite their sources.
May support once-daily nitrendipine for daytime BP control in outpatients; leaves open need for RCTs to confirm 24-hour efficacy.
The understanding of blood pressure (BP) and heart rate (HR) variation, circadian changes, and the responses to nonclinical situations has been improved by automated ambulatory recordings. The antihypertensive efficacy of a once-daily regimen (10/20 mg) of nitrendipine was evaluated in detail using the lightest available portable device equipped with an oscillometric blood pressure (BP) recorder (SpaceLabs 90202, weight 480 g) devoid of any electrode. A good antihypertensive effect throughout the day in 20 outpatients could be demonstrated. No significant change of BP could be found in early morning and wake-up period; HR was not significantly affected after 6 weeks of oral therapy.
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Meyer‐Sabellek et al. (1988) studied Hypertension (n=20). Nitrendipine was evaluated on Blood pressure and heart rate variation.
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