July 1, 1985Clinical Pharmacology & Therapeutics
Effects of chronic nitrendipine on casual (office) and 24-hour ambulatory blood pressure
Why the study?
Does chronic nitrendipine therapy reduce casual and 24-hour ambulatory blood pressure in subjects with mild to moderate essential hypertension?
Population
22 subjects with mild to moderate essential hypertension
Comparison
Chronic nitrendipine therapy vs Baseline (before maintenance monotherapy)
Design
Cohort
Authors
Discussion
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Member takes
Implication
Ambulatory monitoring may be needed to confirm nitrendipine effects beyond office BP; leaves open consistent 24-hour coverage in mild hypertension.
Structured PICO
Does chronic nitrendipine therapy reduce casual and 24-hour ambulatory blood pressure in subjects with mild to moderate essential hypertension?
P
Population
22 subjects with mild to moderate essential hypertension
I
Intervention
Chronic nitrendipine therapy (mean dose 71 +/- 15 mg/day in the controlled group)
C
Comparator
Baseline (before maintenance monotherapy)
O
Outcome
Blood pressure (casual/office and 24-hour ambulatory) and heart rate responsessurrogate
Chronic nitrendipine lowers office and home blood pressure but may not reduce blood pressure during work periods, highlighting the value of ambulatory BP monitoring.
Cite This Study
White et al. (1985) studied this question.