Why the study?
Does acute and chronic nitrendipine administration lower blood pressure and preserve circadian rhythms in patients with mild-to-moderate arterial hypertension?
Population
10 patients with mild-to-moderate arterial hypertension
Comparison
Nitrendipine 20 mg single dose and 20 mg daily… vs Placebo and acute administration
Design
RCT, randomized single dose
Follow-up
2 months
Authors
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May favor chronic over acute nitrendipine for sustained BP control in mild hypertension; extends RCT data on rhythm-preserving CCBs.
Does acute and chronic nitrendipine administration lower blood pressure and preserve circadian rhythms in patients with mild-to-moderate arterial hypertension?
Chronic administration of nitrendipine effectively lowers blood pressure while preserving circadian rhythms in patients with mild-to-moderate hypertension.
Mele et al. (1992) studied this question.
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