Why the study?
Does once-daily nitrendipine control blood pressure as effectively as twice-daily dosing in elderly hypertensive patients?
Population
22 elderly patients over 65 years of age with a systolic blood pressure greater than 170 mmHg and a…
Comparison
Nitrendipine once daily. vs Nitrendipine twice daily.
Design
RCT, Randomized equally to two groups., Double-blind, with patients in the…
Follow-up
6 weeks at preferred dosage
Authors
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Once-daily nitrendipine fails to lower SBP in elderly hypertensives; supports twice-daily regimens and guides future dosing trials.
Does once-daily nitrendipine control blood pressure as effectively as twice-daily dosing in elderly hypertensive patients?
In elderly hypertensive patients, twice-daily nitrendipine is necessary to adequately reduce systolic blood pressure, although once-daily dosing is sufficient for diastolic blood pressure control.
Pandita-Gunawardena et al. (1987) studied this question.
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