Key result
Nitrendipine treatment for 5 weeks reduced clinic supine blood pressure from 152/96 to 134/84 mm Hg and attenuated pressor responses to norepinephrine but not to angiotensin II.
Why the study?
Does nitrendipine alter systemic pressor responses to norepinephrine and angiotensin II in subjects with mild, uncomplicated hypertension?
Population
11 subjects with mild, uncomplicated hypertension
Comparison
Nitrendipine for 5 weeks vs Placebo
Design
RCT
Follow-up
5 weeks
Authors
Loading...
Suggests utility in sympathetic-dominant hypertension; extends mechanistic differentiation of dihydropyridine effects in RCT.
RCT (n=11)
Does nitrendipine alter systemic pressor responses to norepinephrine and angiotensin II in subjects with mild, uncomplicated hypertension?
Simon et al. (1984) conducted an RCT in mild, uncomplicated hypertension (n=11). Nitrendipine vs. Placebo was evaluated on Systemic pressor responses to norepinephrine (NE) and angiotensin II (AII) and clinic supine blood pressure. Nitrendipine treatment for 5 weeks reduced clinic supine blood pressure from 152/96 to 134/84 mm Hg and attenuated pressor responses to norepinephrine but not to angiotensin II.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: