What question did this study set out to answer?

To evaluate the renal hemodynamic and humoral responses to the calcium entry blocker nitrendipine in patients with arterial hypertension.

January 1, 1986Archives of Internal Medicine

Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension

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Why the study?

Does nitrendipine modify hemodynamics and renal function in patients with hypertension and normal renal function?

Population

13 patients with hypertension and normal renal function

Design

Cohort

Authors

RPRoberto PedrinelliGeneral / Preventive / Lipids

Discussion

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Implication

Nitrendipine may lower BP while preserving renal hemodynamics in hypertension; leaves open comparative efficacy pending randomized trials.

Key Points

To evaluate the renal hemodynamic and humoral responses to the calcium entry blocker nitrendipine in patients with arterial hypertension.
Administered nitrendipine to 13 hypertensive patients with normal baseline renal function.
Measured renal blood flow, glomerular filtration rate, mean arterial pressure, cardiac output, plasma catecholamines, renin activity, and aldosterone levels.
Nitrendipine decreased mean arterial pressure and total peripheral resistance, but produced no significant change in renal blood flow, glomerular filtration rate, or cardiac output.
Plasma catecholamines and plasma renin activity increased significantly, while plasma aldosterone and plasma volume remained largely unchanged.
Reductions in mean arterial pressure correlated inversely with baseline renin levels and positively with patient age.

Structured PICO

Does nitrendipine modify hemodynamics and renal function in patients with hypertension and normal renal function?

Population

13 patients with hypertension and normal renal function

Intervention

Nitrendipine (long-term)

Outcome

Renal blood flow (RBF) and glomerular filtration rate (GFR)surrogate

Nitrendipine effectively lowers blood pressure while preserving renal function, with potentially greater efficacy in older patients and those with low renin levels.

Cite This Study

Roberto Pedrinelli (1986) studied this question.

synapsesocial.com/papers/6a712a888031ec7bb1dccd5f https://doi.org/10.1001/archinte.146.1.62

Topics

Hypertension management

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Implication

Nitrendipine may lower BP while preserving renal hemodynamics in hypertension; leaves open comparative efficacy pending randomized trials.

Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Nitrendipine, a calcium-entry blocker. Renal and humoral effects in human arterial hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider