Key result
Verapamil, enalapril, and nitrendipine reduce 24-hour BP, with verapamil and enalapril providing superior nighttime reduction.
Why the study?
Ambulatory blood pressure monitoring has potential advantages over conventional measurement but its routine use in treating hypertensives is limited by lack of prognostic validity and high cost.
Does ambulatory blood pressure monitoring better evaluate the efficacy of antihypertensive drugs compared to conventional measurement?
Population
Hypertensive patients
Comparison
Verapamil SR 240 mg, enalapril 20 mg, nitrendipine 20 mg vs placebo once daily
Design
Multicenter double-blind parallel group study
Authors
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ABPM lacks prognostic validity for routine antihypertensive evaluation; leaves open targeted use in research or high-risk subgroups.
RCT
Double-blind
parallel group
Yes
Does ambulatory blood pressure monitoring better evaluate the efficacy of antihypertensive drugs compared to conventional measurement?
Ambulatory blood pressure monitoring can detect differences in the 24-hour efficacy profile of antihypertensive drugs that are missed by conventional sphygmomanometry.
Mancia et al. (1992) conducted an RCT in Hypertension. Verapamil SR, enalapril, and nitrendipine vs. Placebo was evaluated on 24-hour mean blood pressure reduction. Verapamil SR, enalapril, and nitrendipine reduced 24-hour mean blood pressure compared to placebo, with verapamil and enalapril more effectively lowering nighttime blood pressure than nitrendipine.