June 1, 1993American Journal of Hypertension
Ambulatory Blood Pressure Monitoring in the Design of Studies on Antihypertensive Drug Efficacy
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
May enable smaller placebo-free antihypertensive trials; leaves open protocol standardization amid technical constraints.
Structured PICO
I
Intervention
Ambulatory blood pressure monitoring (ABPM) in study design
ABPM offers significant methodological advantages for antihypertensive drug trials, potentially reducing required sample sizes and eliminating the need for placebo groups, despite some current technical limitations.
Limitations
- inability of automatic ABPM to consistently provide accurate BP readings
- inability to estimate BP variability
- hourly average BPs are less reproducible than 24 h counterpart
Cite This Study
Mancia et al. (1993) studied this question.