April 1, 1995Clinical Science
Selective Enhancement of α2-Adrenoceptor-Mediated Vasoconstriction in Insulin-Dependent Diabetic Patients with Microalbuminuria
Key result
Insulin-dependent diabetic patients with microalbuminuria demonstrated enhanced vascular responsitivity to clonidine compared with normoalbuminuric patients and non-diabetic controls (P<0.001).
Why the study?
Does alpha-1 or alpha-2 adrenergic receptor sensitivity differ in insulin-dependent diabetic patients with microalbuminuria compared to those without and non-diabetic controls?
Population
15 insulin-dependent diabetic patients with microalbuminuria, 15 insulin-dependent diabetic patients with…
Comparison
Infusion of alpha-1 adrenergic agonist… vs Comparison between the three groups
Design
Cross-sectional
Authors
Discussion
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Implication
May link alpha-2 hyperresponsiveness to nephropathy progression in IDDM; hypothesis-generating, needs prospective confirmation before clinical relevance.
Study Design
Type
Observational (n=44)
Structured PICO
Does alpha-1 or alpha-2 adrenergic receptor sensitivity differ in insulin-dependent diabetic patients with microalbuminuria compared to those without and non-diabetic controls?
P
Population
44 subjects comprising 15 insulin-dependent diabetics with microalbuminuria, 15 with normal albumin excretion, and 14 non-diabetic controls.
E
Exposure
Infusion of alpha-1 adrenergic agonist phenylephrine and alpha-2 adrenergic agonist clonidine (infusion rates 16-2048 ng/min)
C
Comparator
Comparison between the three groups (diabetic with microalbuminuria, diabetic with normal albumin excretion, and non-diabetic controls)
O
Outcome
Vascular constrictive responses measured in dorsal hand veinssurrogate
Main Result
p-value: p=< 0.001
Insulin-dependent diabetic patients with microalbuminuria exhibit selectively enhanced alpha-2 adrenoceptor-mediated vasoconstriction, which may contribute to systemic and intraglomerular hypertension and diabetic nephropathy.
Cite This Study
Bodmer et al. (1995) conducted an observational in Insulin-dependent diabetes (n=44). Insulin-dependent diabetes with microalbuminuria vs. Normoalbuminuric insulin-dependent diabetic patients and non-diabetic subjects was evaluated on Vascular constrictive responses to clonidine in dorsal hand veins (p=< 0.001). Insulin-dependent diabetic patients with microalbuminuria demonstrated enhanced vascular responsitivity to clonidine compared with normoalbuminuric patients and non-diabetic controls (P<0.001).