What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Essential hypertension and non-insulin dependent diabetes mellitus. Intervention: Microalbuminuria vs. Normoalbuminuria and healthy controls. Primary outcome: Whole-body glucose utilization (mg/kg/min) (p=< 0.01).

What question did this study set out to answer?

To investigate the relationship between insulin resistance and albumin excretion rate in nondiabetic patients with essential hypertension and patients with non-insulin dependent diabetes mellitus.

October 1, 1992Journal of the American Society of Nephrology

Close relationship between microalbuminuria and insulin resistance in essential hypertension and non-insulin dependent diabetes mellitus.

Q: What are the key findings of this study?

Microalbuminuria in essential hypertension and NIDDM was associated with significantly lower whole-body glucose utilization compared to normoalbuminuric patients and healthy controls.

Q: What question did this study set out to answer?

To investigate the relationship between insulin resistance and albumin excretion rate in nondiabetic patients with essential hypertension and patients with non-insulin dependent diabetes mellitus.

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Key result

Microalbuminuria in essential hypertension and NIDDM was associated with significantly lower whole-body glucose utilization compared to normoalbuminuric patients and healthy controls.

Population

25 nondiabetic patients with essential hypertension, 28 patients with non-insulin dependent diabetes…

Design

Cross-sectional

Authors

RNR. NosadiniUniversity of Padua MCM. R. CipollinaUniversity of Padua ASAnna SoliniGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Microalbuminuria may mark insulin resistance in hypertension and NIDDM; leaves open causality and need for prospective outcome trials.

Key Points

To investigate the relationship between insulin resistance and albumin excretion rate in nondiabetic patients with essential hypertension and patients with non-insulin dependent diabetes mellitus.
Evaluated 25 nondiabetic patients with essential hypertension (divided by presence of microalbuminuria) and 28 patients with non-insulin dependent diabetes mellitus (subdivided by presence of hypertension and microalbuminuria), compared against age-, sex-, and weight-matched healthy controls.
Measured whole-body glucose utilization during a euglycemic hyperinsulinemic clamp (40 mU/m2/min) using a continuous 6,6 2H2 glucose tracer dilution infusion.
Determined maximal velocity (Vmax) of sodium-lithium countertransport in red blood cells across all subgroups.
Whole-body glucose utilization was significantly lower in hypertensives with microalbuminuria than in hypertensives without microalbuminuria and controls (3.41 ± 0.51 vs 6.52 ± 0.62 vs 7.03 ± 0.48 mg/kg/min; mean ± SE).
Diabetic patients with microalbuminuria or hypertension exhibited significantly lower glucose utilization (1.86 ± 0.31 to 2.21 ± 0.39 mg/kg/min) than normotensive diabetic patients without microalbuminuria (5.98 ± 0.77 mg/kg/min) and controls (5.52 ± 0.92 mg/kg/min; P < 0.01).
Red blood cell sodium-lithium countertransport Vmax was significantly elevated in both hypertensive and diabetic patients with microalbuminuria compared to their normoalbuminuric counterparts and healthy controls.

Study Design

Type

Cross-Sectional

Structured PICO

Population

25 nondiabetic patients with essential hypertension, 28 patients with NIDDM, and healthy matched controls evaluated for insulin resistance and albumin excretion.

Comparator

Healthy subjects matched for age, sex, and weight

Outcome

Whole-body glucose utilization during euglycemic hyperinsulinemic clampsurrogate

Main Result

Absolute Event Rate: 3.41% vs 6.52%

p-value: p=< 0.01

Microalbuminuria is closely associated with insulin resistance and altered cellular sodium-lithium countertransport in both essential hypertension and non-insulin dependent diabetes mellitus.

Cite This Study

Nosadini et al. (1992) conducted a cross-sectional in Essential hypertension and non-insulin dependent diabetes mellitus. Microalbuminuria vs. Normoalbuminuria and healthy controls was evaluated on Whole-body glucose utilization (mg/kg/min) (p=< 0.01). Microalbuminuria in essential hypertension and NIDDM was associated with significantly lower whole-body glucose utilization compared to normoalbuminuric patients and healthy controls.

synapsesocial.com/papers/6a9410a8235a0bf22c92d89d https://doi.org/10.1681/asn.v34s56

Topics

Hypertension management

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Close relationship between microalbuminuria and insulin resistance in essential hypertension and non-insulin dependent diabetes mellitus.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Close relationship between microalbuminuria and insulin resistance in essential hypertension and non-insulin dependent diabetes mellitus.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

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